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PSP Alien Syndrome is a video game developed by Totally Games and published by Sega for the PlayStation Portable (PSP) in 2007. It is a sci-fi action role-playing game that takes place on a spaceship, where the player takes on the role of a space marine named Aileen Harding who must fight her way through hordes of alien creatures to save her fellow crew members.

The game features a variety of weapons and abilities that players can use to take down the alien enemies, including guns, grenades, and special powers like a healing ability or a temporary shield. There are also various types of aliens to fight, each with their own strengths and weaknesses.

In addition to the single-player campaign, Alien Syndrome also features a multiplayer mode where players can team up with friends to take on the alien hordes together. The multiplayer mode allows players to customize their characters and share loot, making it a fun and engaging cooperative experience.

Overall, PSP Alien Syndrome is a fast-paced and action-packed game that offers a fun sci-fi adventure for PSP gamers who enjoy action RPGs and cooperative multiplayer modes.